A novel mRNA vaccine elicits a weak initial antibody response; which adaptation is most likely to enhance long-term protection through increased antibody affinity maturation in germinal centers?

💡 Explanation

Including a TLR agonist adjuvant enhances T follicular helper cell activation, which promotes B cell affinity maturation in germinal centers because this boosts the selection of B cells with higher affinity antibodies. Therefore, long-term protection is improved rather than merely changing mRNA properties or dosage.

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