A patient with a thyroid tumor is treated with radioactive iodine, destroying thyroid tissue. Which consequence is most likely due to disrupted endocrine feedback?

💡 Explanation

Radioactive iodine ablates thyroid tissue, reducing thyroid hormone production. Because thyroid hormones negatively regulate TSH secretion via a negative feedback loop, less thyroid hormone results in increased TSH secretion by the pituitary; therefore, TSH rises, rather than other hormonal axes being directly affected by thyroid ablation.

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