A patient with iodine deficiency consumes goitrogenic foods (cassava). Which feedback response most likely exacerbates thyroid enlargement?

💡 Explanation

Goitrogens inhibit thyroid hormone synthesis; because iodine is deficient, the thyroid can't produce enough T3/T4. This leads to chronically elevated TSH (thyroid-stimulating hormone) levels via negative feedback. Therefore, the thyroid enlarges (goiter) due to TSH's growth-promoting effects, rather than increased hormone production directly compensating.

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