A patient with peripheral arterial disease develops a non-healing ulcer on their lower leg despite infection control. Why does impaired angiogenesis compromise wound closure?

💡 Explanation

Impaired angiogenesis limits the formation of new blood vessels, and therefore reduces nutrient and oxygen delivery to the wound bed. Because of this, cells cannot proliferate and synthesize the extracellular matrix necessary for tissue regeneration, leading to a non-healing ulcer, rather than efficient repair.

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