A patient with rheumatoid arthritis takes high-dose aspirin, inhibiting COX-1 and COX-2. Which consequence follows from chronic COX inhibition, impacting prostaglandin-mediated processes?

💡 Explanation

High-dose aspirin inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis, because prostaglandins mediate inflammation and pain sensitization. Therefore, chronic COX inhibition results in reduced inflammation and pain sensitization, rather than the opposite effects or affecting renal function, which is regulated by different prostaglandins.

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