A woman with a history of irregular menstruation is prescribed clomiphene citrate to improve fertility. Which effect best explains how clomiphene promotes ovulation?

💡 Explanation

Clomiphene acts as a selective estrogen receptor modulator (SERM) that blocks estrogen receptors in the hypothalamus. Because this decreases negative feedback on gonadotropin-releasing hormone (GnRH), FSH and LH secretion increases, stimulating ovulation, therefore option C is correct rather than options A, B, and D, which involve different mechanisms.

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