After successful pathogen clearance in lung tissue, which mechanism explains why inflammation resolves rather than becoming chronic, considering macrophage polarization?

💡 Explanation

Inflammation resolves following pathogen clearance due to the actions of M2 macrophages, which produce specialized pro-resolving mediators like lipoxins and resolvins; these actively suppress pro-inflammatory signaling. Therefore, resolution is achieved by active signaling rather than persistent inflammatory cascades, because these lead to chronic conditions.

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