As individuals age, and mitochondrial function declines, which consequence follows regarding the impact of reactive oxygen species (ROS) on musculoskeletal health?

💡 Explanation

Elevated ROS levels from diminished mitochondrial function cause oxidative damage, leading to accelerated collagen breakdown in tendons and ligaments because ROS activate matrix metalloproteinases. Therefore, connective tissues weaken with age, rather than being strengthened or protected, due to impaired antioxidant defenses.

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