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Human Body & Health

During nervous system development, what causes some axons to fail to connect correctly to their target neurons, resulting in neural circuit errors?

A)Excessive glial cell proliferation
B)Inadequate neurotrophic factor signaling
C)Premature synapse pruning initiation
D)Increased inhibitory neurotransmitter release

💡 Explanation

Inadequate neurotrophic factor signaling leads to axon retraction and failure to establish stable synapses because these factors are crucial for neuronal survival and axonal growth. Therefore, the absence of sufficient neurotrophic support causes incorrect connections, rather than glial cell proliferation or altered neurotransmitter levels, which play different roles.

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