During prolonged stress, what happens to synaptic neurotransmitter availability in the prefrontal cortex that impairs cognitive function?

💡 Explanation

Increased reuptake transporter activity removes neurotransmitters more quickly from the synaptic cleft, reducing their availability. Because of this reduced availability, the prefrontal cortex cannot sustain normal activity. Therefore, cognitive function is impaired, rather than enhanced by receptor changes.

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