If a burn patient experiences significant keratinocyte damage, which consequence follows for trans-epidermal water loss?

💡 Explanation

Keratinocytes, which produce keratin, are crucial for the skin's barrier function. Because keratinocytes form a tight barrier that prevents excessive water loss, significant damage to them increases water permeability; therefore, trans-epidermal water loss increases substantially, rather than remaining unchanged or fluctuating unpredictably, as alternative barrier mechanisms are overwhelmed.

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