If a deep dermal wound in a patient with peripheral vascular disease develops a chronic non-healing ulcer, which consequence is the MOST likely to prolong the inflammatory phase?

💡 Explanation

Chronic non-healing wounds in patients with vascular disease often remain in a prolonged inflammatory phase because inadequate blood supply prevents efficient clearance of debris and inflammatory cells. This results in persistent neutrophil infiltration, causing continued reactive oxygen species production and tissue damage; therefore, prolonged inflammation results rather than a shift to the proliferative phase because of impaired resolution signals.

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