If a dorsal horn interneuron releases enkephalin in response to descending modulation after an acute injury, which consequence follows?

💡 Explanation

Descending modulation activates enkephalin-releasing interneurons, causing a reduction in pain signal transmission because enkephalin inhibits substance P release from nociceptors, blocking signal propagation. Therefore, the pain signal is attenuated, rather than enhanced, and it is a broader effect than directly inhibiting Substance P release.

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