If a genetically modified T-cell expressing a chimeric antigen receptor (CAR) encounters a tumor cell displaying the target antigen, which consequence follows in the tumor microenvironment?

💡 Explanation

CAR T-cells, upon binding to the target antigen on tumor cells, become activated. Because this activation leads to the release of large quantities of cytokines that can result in a localized cytokine storm near the tumor, therefore, the localized cytokine storm initiation is the most likely outcome rather than immune evasion which would counteract the purpose of CAR-T therapy.

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