If a long-distance runner experiences a sharp decline in performance despite maintaining pace, which consequence related to intramuscular lactate accumulation is most likely?

💡 Explanation

Lactate accumulation during intense exercise leads to increased acidity within muscle cells. This increased acidity from lactate inhibits the activity of phosphofructokinase, a key glycolytic enzyme, because the reduced pH disrupts its allosteric regulation; therefore, glycolysis slows down, rather than ATP production being enhanced or calcium binding directly affected.

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