If a macrophage fails to transition to an M2 phenotype during wound healing, which consequence follows regarding the inflammation?

💡 Explanation

The failure of macrophages to transition to M2 phenotype prevents the release of anti-inflammatory cytokines and growth factors, resulting in ongoing activation of NF-kB and continued production of pro-inflammatory cytokines. Therefore, inflammation will persist, rather than being resolved, because the resolution phase requires M2 macrophages.

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