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Life Sciences & Medicine

If a mutation disables the G protein in olfactory sensory neurons, which consequence follows?

A)Increased action potential firing rate
B)Heightened sensitivity to odorants
C)Inability to detect specific odorants
D)Enhanced enzymatic breakdown of cAMP

💡 Explanation

Odorant receptors activate G proteins, triggering adenylyl cyclase to produce cAMP, which opens ion channels leading to neuron depolarization. Because a disabled G protein prevents cAMP production and subsequent depolarization, the neuron cannot detect odorants, rather than other sensory transduction pathways.

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