If a mutation disables the G1 checkpoint in rapidly dividing lung cancer cells stimulated by epidermal growth factor (EGF), which consequence follows regarding apoptosis?

💡 Explanation

When the G1 checkpoint is disabled, cells with DNA damage proceed to S phase, leading to mitotic catastrophe and genomic instability during cell division. Because mitotic catastrophe often results in cell death pathways being overridden, therefore apoptosis is reduced, rather than caspase inhibition directly blocking apoptosis.

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