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Human Body & Health

If a neuron's ubiquitin-proteasome system degrades less misfolded alpha-synuclein aggregate, which consequence follows?

A)Increased neurotransmitter receptor synthesis
B)Enhanced axonal transport efficiency
C)Reduced mitochondrial oxidative phosphorylation
D)Increased Lewy body formation risk

💡 Explanation

Because the ubiquitin-proteasome system normally clears misfolded proteins, reduced function leads to increased accumulation of alpha-synuclein aggregates. This increased aggregation elevates the risk of Lewy body formation, therefore increasing the risk of Parkinson's disease rather than enhancing cellular functions.

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