If a novel drug aims to reduce inflammation by targeting the NF-κB signaling pathway in immune cells stimulated by lipopolysaccharide (LPS), which consequence is most likely to occur?

💡 Explanation

Blocking the NF-κB pathway inhibits the transcription of genes encoding pro-inflammatory cytokines like TNF-α and IL-6, because NF-κB acts as a key transcription factor in their expression. Therefore, cytokine production decreases, rather than alternative scenarios like enhanced ROS or inflammasome activation, which rely on different upstream mechanisms.

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