If a novel enveloped virus binds ACE2 in human lung epithelial cells, stimulating the pyroptosis pathway in macrophages, which consequence follows?

💡 Explanation

Pyroptosis is a highly inflammatory form of programmed cell death. Because macrophages release intracellular contents and cytokines upon pyroptosis, this stimulates an exaggerated inflammatory response and cytokine storm, rather than reducing inflammation. Therefore, the viral stimulation of pyroptosis causes detrimental hyperinflammation, rather than immune regulation or NET reduction.

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