If a patient chronically overuses NSAIDs like ibuprofen, which consequence becomes likely regarding localized inflammation resolution?

💡 Explanation

Long-term NSAID overuse impairs inflammation resolution because they inhibit cyclooxygenase (COX), reducing prostaglandin and lipoxin synthesis which are crucial for switching from pro-inflammatory to resolution phases; therefore resolution is impaired, rather than enhanced, and macrophage function is indirectly affected.

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