If a patient chronically underhydrates while taking thiazide diuretics for hypertension management, which consequence related to kidney function is most probable?

💡 Explanation

Thiazide diuretics can reduce urine volume and increase calcium reabsorption in the kidneys, leading to higher calcium oxalate concentrations in the urine. Underhydration exacerbates this supersaturation, promoting crystallization and stone formation, because the inhibitor mechanisms are overwhelmed. Therefore, kidney stone formation increases, rather than other changes in renal function.

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