If a patient develops type 2 diabetes despite consistently injecting insulin, which mechanism involving GLUT4 transporters primarily explains this resistance at the cellular level?

💡 Explanation

Insulin resistance in type 2 diabetes often involves impaired GLUT4 vesicle fusion with the cell membrane. This reduces glucose uptake into cells, because even with insulin present, GLUT4 transporters cannot effectively move to the membrane to facilitate glucose transport; therefore, cellular glucose uptake decreases, rather than increasing GLUT4 expression or initial translocation steps.

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