If a patient exhibits inflammation due to an overactive NF-κB pathway secondary to chronic TNF-α signaling in intestinal epithelial cells, which intervention targets the core problem?

💡 Explanation

A specific IKK inhibitor would target the NF-κB activation directly, because IKK phosphorylates IκB, leading to NF-κB activation. Therefore, inhibiting IKK prevents NF-κB driven transcription of inflammatory cytokines, rather than generally suppressing COX enzymes or only indirectly affecting the pathway.

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