If a patient experiences chronic pain despite taking NSAIDs, which consequence involving substance P release at the spinal cord is most likely?

💡 Explanation

Increased dorsal horn neuron excitation is likely because substance P, released by nociceptors, enhances pain signals in the spinal cord. Therefore, the pain persists despite NSAIDs targeting prostaglandin synthesis, rather than directly affecting substance P release and its downstream effects on dorsal horn neurons.

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