If a patient with chronic anemia receives a blood transfusion using blood stored for an extended period, which consequence follows regarding oxygen delivery?

💡 Explanation

Extended storage of blood decreases 2,3-BPG levels in red blood cells; 2,3-BPG normally reduces hemoglobin's oxygen affinity. Because of this depletion, hemoglobin's affinity for oxygen increases, therefore oxygen release to tissues becomes impaired, rather than enhanced oxygen offloading or chloride shift.

• A catheterized patient develops a persistent urinary tract infection despite antibiotic treatment. Which mechanism explains why the *E. coli* biofilm exhibits resistance when planktonic bacteria are susceptible?
• Why does uncontrolled proliferation occur even with DNA damage when a growth factor receptor, such as EGFR, has a mutation inhibiting its internalization upon ligand binding?
• Following a vasectomy, why does a semen analysis sometimes show non-motile sperm in the initial weeks?
• Why does hyponatremia sometimes occur in patients with nephrotic syndrome, despite total body sodium often being elevated?
• If a mutation disables the EGFR receptor's ability to internalize after growth factor binding in lung cancer cells, which consequence follows?
• If a drug inhibits pancreatic beta cell glucokinase in a patient with Type 2 diabetes already exhibiting insulin resistance, which consequence follows?