If a researcher inhibits phospholipase A2 (PLA2) in immune cells responding to tissue damage, which consequence follows regarding the inflammatory pathway?

💡 Explanation

Inhibiting PLA2 reduces arachidonic acid release from cell membranes, because PLA2 catalyzes this initial step in prostanoid synthesis. Therefore, arachidonic acid and downstream prostanoids like prostaglandins are reduced, rather than leukotriene production increasing or COX-2 activity rising because the substrate is absent.

• If a cancer cell population exhibits increased growth despite checkpoint activation, which mechanism involving receptor tyrosine kinases (RTKs) is most likely driving this resistance to apoptosis?
• If a woman with regular menstrual cycles experiences elevated stress, what happens to GnRH pulsatility?
• A sedentary individual experiences persistent swelling in their lower extremities. Which mechanism explains why decreased physical activity causes edema in this scenario?
• What distinguishes angiotensin II's vasoconstrictive effect in chronic hypertension from its role in acute blood pressure regulation?
• Why does cartilage breakdown accelerate in an osteoarthritic knee joint under high compressive loads?
• If a pulmonary embolism blocks blood flow to a portion of the lung, what distinguishes the observed hypoxemia from hypoxemia due to high altitude?