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Human Body & Health

If a researcher introduces a non-selective COX inhibitor directly into a cell culture undergoing prostaglandin-mediated inflammation, which consequence follows?

A)Increased TNF-α cytokine production
B)Reduced synthesis of all prostanoids
C)Selective suppression of TXA2 only
D)Enhanced leukotriene pathway activity

💡 Explanation

The non-selective COX inhibitor blocks both COX-1 and COX-2 enzymes, inhibiting the entire prostaglandin synthesis pathway; therefore, the production of all prostanoids (prostaglandins, thromboxanes, and prostacyclins) is reduced, rather than a selective effect on one specific prostanoid, because the entire pathway from arachidonic acid is affected.

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