If a researcher introduces a novel compound inhibiting NF-κB activation in macrophages during an inflammatory response to LPS (lipopolysaccharide), which consequence follows?

💡 Explanation

Reduced NF-κB activation directly inhibits the transcription of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β because NF-κB is a key transcription factor for these genes. Therefore, the expression of pro-inflammatory cytokines is reduced, rather than enhanced prostaglandin synthesis or increased cytokine transcription.

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