If an individual receives a booster vaccine dose years after the primary series, which consequence regarding antibody affinity is most likely?

💡 Explanation

Booster vaccines trigger the germinal center reaction again, driving affinity maturation. This increases the average antibody affinity, because memory B cells are reactivated and undergo further rounds of mutation and selection. Therefore, affinity increases, rather than remaining static or decreasing due to original B cell dominance.

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