If an individual's synovial joint inflammation chronically overproduces pro-inflammatory cytokines, overwhelming natural regulatory mechanisms, which outcome involving the resolution phase of inflammation is most likely?

💡 Explanation

Chronic inflammation overwhelms resolution pathways because excessive pro-inflammatory cytokine production exhausts the capacity to produce specialized pro-resolving mediators (SPMs) like lipoxins and resolvins. Therefore, impaired SPM formation hinders inflammation resolution, rather than accelerating it through apoptosis or clearance of cells.

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