If cancer cells develop a mutation that disables EGFR (epidermal growth factor receptor) internalization after growth factor binding, which consequence follows for cell cycle progression?

💡 Explanation

Sustained activation of downstream signaling occurs because the mutated EGFR remains on the cell surface, continuously signaling. This bypasses normal checkpoint controls, therefore promoting uncontrolled cell division rather than triggering apoptosis or cell cycle arrest. Reduced internalization diminishes regulatory feedback mechanisms.

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