If ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), is administered following a bone fracture, which consequence affecting bone healing is most likely?

💡 Explanation

Ibuprofen inhibits cyclooxygenase (COX) enzymes, decreasing prostaglandin synthesis, which is necessary for the inflammatory phase of fracture healing. Reduced prostaglandins impair callus remodeling because bone resorption is lessened; therefore, healing is delayed, rather than accelerated. Callus formation, differentiation, and proliferation rates are not directly enhanced.

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