If specialized pro-resolving mediators (SPMs) are deficient following lung injury, which consequence affecting the inflammatory cascade is most likely?

💡 Explanation

A deficiency in SPMs impairs inflammation resolution because their mechanism terminates neutrophil infiltration by disrupting chemoattractant signaling and promoting macrophage phagocytosis of apoptotic neutrophils. Therefore, neutrophil infiltration fails to cease, rather than resolving normally with decreased neutrophil presence and increased phagocytosis.

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