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Human Body & Health

What causes increased blood ammonia levels when the liver's capacity for urea cycle activity is reduced?

A)Elevated hepatic glycogen synthesis
B)Impaired detoxification of ammonia
C)Increased bile acid production
D)Stimulated gluconeogenesis from lactate

💡 Explanation

Impaired liver function compromises the urea cycle, the main mechanism for converting toxic ammonia into urea for excretion. Therefore, ammonia detoxification is reduced, causing blood ammonia levels to rise, rather than glycogen synthesis increasing or alternative metabolic pathways dominating.

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