What happens to a differentiating stem cell's gene expression profile when transcription factors activate lineage-specific genes?

💡 Explanation

Stem cell differentiation involves a carefully orchestrated shift in gene expression. Activation of lineage-specific genes represses the genes maintaining pluripotency via epigenetic mechanisms, because differentiation is mutually exclusive with pluripotency; therefore, the expression of pluripotency genes decreases, rather than continues or remains unchanged.

• If a deep-sea hydrothermal vent community relies primarily on chemosynthesis, which consequence follows regarding energy production?
• If a mosquito infected with malaria initially probes a host but fails to draw blood, which consequence follows?
• If a virus infects a bacterial cell, which consequence follows due to the lytic cycle?
• What happens to donated red blood cells when ABO-incompatible blood is transfused into a recipient?
• If a forest fire wipes out a large section of a pine forest community, which consequence follows the initial devastation?
• What happens to blood glucose levels when insulin resistance increases significantly in peripheral tissues?