What happens to portal vein pressure when liver stellate cells, activated by TGF-β during cirrhosis, deposit excessive collagen in the space of Disse?

💡 Explanation

Hepatic stellate cell activation leads to excessive collagen deposition in the space of Disse, obstructing blood flow through the liver sinusoids. Because of this increased resistance, portal vein pressure increases, causing portal hypertension, rather than remaining stable or decreasing.

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