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← ScienceWhich bonding outcome is disrupted by deuterium substitution during kinetic analysis?
A)Intermolecular van der Waals attraction
B)Intramolecular nonpolar covalent bonding
C)Intermolecular hydrogen bond strength✓
D)Intramolecular metallic crystal lattice
💡 Explanation
Isotopic replacement impacts vibrational frequency and zero point energy; therefore, the kinetic isotope effect (KIE) affects hydrogen bond strength to favor protium rather than deterium, because C-H bonds break sooner via zero-point vibrational difference.
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