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Which bonding outcome is disrupted by deuterium substitution during kinetic analysis?

A)Intermolecular van der Waals attraction
B)Intramolecular nonpolar covalent bonding
C)Intermolecular hydrogen bond strength
D)Intramolecular metallic crystal lattice

💡 Explanation

Isotopic replacement impacts vibrational frequency and zero point energy; therefore, the kinetic isotope effect (KIE) affects hydrogen bond strength to favor protium rather than deterium, because C-H bonds break sooner via zero-point vibrational difference.

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