Which consequence results when a complex protein's folding energy landscape exhibits multiple local minima?

💡 Explanation

Protein misfolding aggregation occurs because the protein folding funnel guides the protein into local energy minima, and becomes kinetically trapped; therefore the correctly-folded native state is not reached, rather than the protein adopting its functional, lowest-energy conformation.

• Which performance limitation arises when operating a Carnot heat engine near critical point of working fluid?
• Which restriction arises during electron transport processes, leading to inhibited oxidative phosphorylation?
• Which outcome occurs when aluminum reacts with concentrated hydrochloric acid?
• Which risk increases when a reversible heat engine undergoes runaway melting?
• Which outcome occurs when high gravity bends light?
• Which risk increases when cooling amorphous silica below 0K?