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← ScienceWhich consequence results when a pharmaceutical destabilizes protein's confirmation?
A)Loss of active domain structure✓
B)Increased hydrophobic residue exposure
C)Accelerated alpha helix propagation
D)Enhanced disulfide bridge stabilization
💡 Explanation
Loss of an active domain occurs because the induced-fit action requires the native three-dimensional structure; this loss is due to **conformational change**, therefore biological activity often diminishes irreversibly, rather than other effects like simple changes in local hydrophobicity.
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