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← ScienceWhich consequence results when a protein's tertiary folding is disrupted?
A)Loss of specific binding affinity✓
B)Increased peptide bond hydrolysis rate
C)Reduced alpha-helix secondary structure
D)Spontaneous increase in molecular mass
💡 Explanation
Loss of specific binding affinity occurs because protein function depends critically on structure to correctly position its binding site; denaturation affects intermolecular **Van der Waals interactions**, therefore it loses function rather than peptide hydrolysis, alpha-helix change, or mass changes.
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