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Which consequence results when excess iron accumulates between DNA base pairs?

A)DNA strand break frequency increases
B)Telomere shortening is significantly accelerated
C)Replication fork stalling is always decreased
D)Transcription initiation sites become more efficient

💡 Explanation

Increased free iron promotes Fenton chemistry. This free radical attack drives strand breaks, because the Fenton reaction generates hydroxyl radicals that cleave the DNA backbone, therefore breaks increase rather than telomere change in replication.

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