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← ScienceWhich consequence results when excess unbound intracellular calcium?
A)Mitochondrial membrane potential collapses irreversibly✓
B)ATP production rapidly and sharply increases
C)Glycolysis fully ceases to restore balance
D)Uncontrolled DNA synthesis spontaneously initiates
💡 Explanation
Excess calcium causes mitochondrial permeability transition because this mechanism opens pores in mitochondria, leading to outer membrane permeabilization through protein aggregation effects. Therefore, membrane potential collapses, rather than controlled ATP synthesis or DNA replication elsewhere.
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