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Which consequence results when the Michaelis constant greatly exceeds substrate concentration?

A)Enzyme active site saturation increases
B)Reaction rate becomes zeroth order
C)Catalytic efficiency sharply decreases
D)Allosteric inhibition becomes more effective

💡 Explanation

Low substrate availability relative to the Michaelis constant causes reduced catalytic efficiency because the enzyme will be unbound much of the time due to the enzyme-substrate complex lacking. Therefore efficiency plummets, rather than enhancement of saturation or allosteric effects, which depend instead differently on substrate and inhibitor concentrations.

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