Which failure mode becomes likely when chronic psychological stress impairs proteasome function within muscle cells undergoing age-related sarcopenia?

💡 Explanation

Chronic psychological stress leads to increased cortisol, which inhibits proteasome activity. Because the proteasome is crucial for removing misfolded proteins, its impairment leads to the accumulation of these proteins and contributes to sarcopenia, rather than improved protein quality control; therefore, misfolded protein aggregation is the expected failure mode.

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