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← Nature & AnimalsWhich mechanism causes rapid ATP depletion from active muscle tissue during intense cold exposure and shivering thermogenesis?
A)Inefficient uncoupling of oxidative phosphorylation✓
B)Accumulation of lactic acid from anaerobic metabolism
C)Reduced blood flow due to vasoconstriction
D)Inhibition of creatine phosphokinase activity
💡 Explanation
During shivering, the uncoupling protein 1 (UCP1) within mitochondria allows protons to leak across the inner membrane which bypasses ATP synthase, leading to futile cycling and heat generation because the ATP produced during oxidative phosphorylation is uncoupled. Therefore rapid ATP depletion occurs rather than purely anaerobic metabolism exceeding capacity, reduced flow limiting substrate, or enzyme inhibition.
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