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Which mechanism decreases a protein's stability during thermal unfolding?

A)Hydrogen bond disruption dominates
B)Hydrophobic collapse stabilises misfolding
C)Disulfide bonds get hydrolysed
D)Van der Waals radii increase

💡 Explanation

Thermal unfolding occurs because the kinetic energy exceeds the stabilisation from intermolecular forces; therefore, hydrogen bond disruption dominates, weakening the protein's structure rather than increased van der Waals radii decreasing the protein sizes.

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