Which mechanism disrupts protein folding when exposed to high temperatures in aqueous solution?

💡 Explanation

When proteins are exposed to high temperatures, hydrogen bonds are disrupted because increased thermal energy weakens intermolecular forces, unfolding the protein and exposing hydrophobic regions to water. Therefore, disruption of hydrogen bonds exceeds hydrophobic forces, rather than covalent bond cleavage or ionic bond stabilization which require more extreme or specific chemical conditions.

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