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Human Body & Health

Which mechanism explains why prolonged exposure to neonicotinoid pesticides disrupts insect nervous systems at the synaptic level?

A)Increased acetylcholine receptor degradation
B)Enhanced GABA-gated chloride channel activity
C)Persistent acetylcholine receptor activation
D)Reduced acetylcholinesterase production acutely

💡 Explanation

Neonicotinoids act as agonists of acetylcholine receptors; they bind and persistently activate these receptors, because they are not effectively broken down by acetylcholinesterase. This causes overstimulation and eventual paralysis, therefore persistent receptor activation is the mechanism, rather than degradation or GABA channel modulation.

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